RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
miR-124-3p
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
rattus norvegicus
Detection Methods
qRT-PCR; Immunohistochemistry etc.
Target
NA
Pathway
NA
PubMed ID
Title
"MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts"
Year
2014
Function
"MiR-124 expression is decreased in hypertensive fibroblasts. Overexpression of miR-124 significantly attenuated proliferation, migration, and monocyte chemotactic protein-1 expression of hypertensive fibroblasts by targeting polypyrimidine tract-binding protein 1 and subsequent regulation of Notch1/phosphatase and tensin homolog/FOXO3/p21Cip1 and p27Kip1 signaling. MiR-124 expression is suppressed by histone deacetylases and that treatment of hypertensive fibroblasts with histone deacetylase inhibitors increased miR-124 expression and decreased proliferation and monocyte chemotactic protein-1 production."